Datasets

An agent-readable registry of APIs, datasets, and databases with canonical join keys. Search, filter, and see what each source can join on. Built from the open-source datasources project and refreshed on every deploy.

227 sources · source on GitHub

SourceDomainKindLicenseCostAuthFreqBulkMCPMCP commandJoin keys
AACT (Aggregate Analysis of ClinicalTrials.gov)Public PostgreSQL mirror of ClinicalTrials.gov, refreshed daily by CTTI at Duke, with all protocol and results data normalised into ~50 relational tables for SQL analysis.clinical-biotechregistryAACT-CTTI-Attributionfree-with-registrationaccount-requireddailyyesmcp-existsNCT_IDEUDRACT_NUMBEREU_CT_NUMBERPMIDMESH_TERM
Alpha VantageRealtime and historical market data API covering global equities, FX, crypto, commodities, technical indicators, fundamentals, and macroeconomic series, accessed by ticker symbol with a single query endpoint.finance-marketstime-seriesAlpha-Vantage-Proprietaryfreemiumapi-key-freeintraday (1/5/15/30/60 min), daily, weekly, monthly depending on endpointnomcp-existsTICKERISO_3DATE
AlphaFold Protein Structure DatabaseOpen database of AlphaFold-predicted 3D protein structures for 214M+ UniProt sequences, run by EMBL-EBI with Google DeepMind, served per-accession via JSON API and in bulk per-proteome on Google Cloud Storage and the EBI FTP.bio-genomicsregistryCC-BY-4.0freenoneperiodic, tracking UniProt releases; synced to UniProt release 2025_03yesmcp-needed-high-valueUNIPROT_ACCESSIONPDB_ID
American Gut ProjectCrowdfunded citizen-science microbiome dataset of stool, skin, and oral 16S rRNA samples paired with dietary and lifestyle questionnaires, run by the Knight Lab at UC San Diego.bio-genomicscorpusBSD-3-Clausefreenoneirregularyesmcp-needed-low-valueDOIPMID
ANZCTR (Australian New Zealand Clinical Trials Registry)WHO- and ICMJE-recognised primary clinical trials registry for Australia, New Zealand, and international studies, run by the NHMRC Clinical Trials Centre at the University of Sydney.clinical-biotechregistryANZCTR-Terms-of-Usefreenonecontinuousyesrequires-scrapingNCT_IDWHO_UTN
ArrayExpressEMBL-EBI archive of high-throughput functional genomics experiments (microarray and sequencing), now a collection within BioStudies, with MAGE-TAB metadata and raw sequencing reads brokered to ENA.bio-genomicscorpusEMBL-EBI-Terms-of-Usefreenonecontinuous as submitters release studiesyesmcp-needed-low-valueNCBI_TAXON_IDPMID
arXivOpen-access preprint repository for physics, math, CS, quantitative biology, finance, statistics, EE, and economics, with a public metadata API and bulk full-text mirrors.academiccorpusCC0freenonedailyyesmcp-existsnpx -y @futurelab-studio/latest-science-mcp@latestARXIV_IDDOI
BEA Data API (Bureau of Economic Analysis)US Bureau of Economic Analysis API serving official national, industry, regional, and international economic accounts (GDP, personal income, trade, direct investment).government-open-datamixedUS-Government-Public-Domainfreeapi-key-freevaries by dataset: annual, quarterly, monthlyyesmcp-needed-high-valueDATEFIPS
BindingDBPublic database of measured protein-small-molecule binding affinities (Ki, Kd, IC50, EC50) curated from literature, patents, PubChem bioassays, and ChEMBL.clinical-biotechregistryCC-BY-3.0freenoneupdated when new data are added, usually monthly (release 202606)yesmcp-needed-high-valueUNIPROT_ACCESSIONCHEMBL_IDINCHI_KEYPMID
BioImage ArchiveEMBL-EBI's open, cross-modality archive of life-sciences biological imaging data (light, EM, super-resolution, high-content, whole-slide) plus segmentations and AI training sets, built on BioStudies infrastructure with per-study S-BIAD accessions.bio-genomicscorpusvaries-per-studyfreenonecontinuous on submission; no fixed release cycleyesmcp-needed-low-valueNCBI_TAXON_ID
bioRxiv / medRxivPreprint servers for the life sciences (bioRxiv) and health sciences (medRxiv), exposing preprint metadata (DOI, title, authors, abstract, license, funding) and preprint-to-publication status via a free REST API.academiccorpusAuthor-Selected-CCfreenonecontinuous; new preprints posted dailyyesmcp-existsuvx --from biomcp-python biomcp runnpx -y @futurelab-studio/latest-science-mcp@latestDOIROR
BTS Airline On-Time PerformanceFlight-level on-time performance records for US domestic scheduled carriers, with scheduled/actual times, delays by cause, cancellations, and diversions.government-open-dataevent-streamUS-Government-Public-Domainfreenonemonthlyyesmcp-needed-low-valueDATEUS_STATE_CODE
BTS Freight Analysis Framework (FAF)US origin-destination freight flow estimates by commodity, mode, and FAF zone, in tons, value, and ton-miles across historical, base, and forecast years.government-open-datapanelUS-Government-Public-Domainfreenoneannual provisional updates; new base year roughly every 5 years, aligned to the Commodity Flow Surveyyesmcp-needed-low-valueDATE
BTS Port Performance Freight StatisticsUS DOT program publishing nationally-consistent throughput and capacity metrics (TEU, tonnage, dry bulk) for the largest US ports, hosted as Socrata datasets plus annual reports to Congress.government-open-datamixedUS-Government-Public-Domainfreenoneannual report to Congress; underlying Socrata datasets refreshed monthly-to-annually by seriesyesapi-direct-sufficientDATE
Bureau of Labor Statistics (BLS) Public Data APIUS Bureau of Labor Statistics Public Data API and bulk flat files covering employment, unemployment, wages, prices (CPI/PPI), productivity, job openings, and compensation across dozens of survey programs.government-open-datamixedUS-Government-Public-Domainfreeapi-key-freemonthly for most series; weekly/quarterly/annual underlying cadence varies by surveyyesmcp-existsDATEUS_STATE_CODEFIPS
Cancer Cell Line Encyclopedia (CCLE)Multi-omic characterisation of ~1,000 human cancer cell lines (RNA-seq, WES/WGS, copy number, methylation, proteomics, metabolomics, drug sensitivity), distributed through the Broad Institute's DepMap Portal.bio-genomicsmixedDepMap-Terms-Of-Usefree-non-commercialnoneDepMap releases bi-annually (e.g. 25Q2, 25Q4, 26Q1); historical CCLE Phase I-III drops are staticyesmcp-existsENSEMBL_IDGENE_SYMBOLENTREZ_GENE_IDDOIPMID
Cancer Therapeutics Response Portal (CTRP)Small-molecule sensitivity screen linking hundreds of cancer cell lines to compound area-under-curve responses alongside their genomic, lineage, and expression features.bio-genomicspanelCTD2-Open-Accessfreenonestatic; v2 final release 2015 (v1 2013)yesmcp-needed-low-valueINCHI_KEYGENE_SYMBOL
Cboe DataShopCboe's commercial marketplace for historical and real-time options, equities, futures, and index market data, sold as per-day CSV files and via the Cboe All Access REST API.finance-marketsmixedproprietarypaidapi-key-paiddaily end-of-day files; also tick / intraday products and real-time streaming via APIyesmcp-needed-low-valueTICKERDATE
CBOE Volatility Index (VIX)Daily OHLC time series of the CBOE Volatility Index (VIX) from January 1990 to present, mirrored from the official CBOE CSV by DataHub's Core dataset pipeline.finance-marketstime-seriesODC-PDDL-1.0freenoneapproximately every 4 hours via DataHub Core pipeline; upstream CBOE file updates each US trading dayyesapi-direct-sufficientDATE
Census Building Permits Survey (BPS)Monthly and annual counts of new privately-owned residential building permits authorized in the US, reported at national, state, CBSA, county, and place levels.government-open-datapanelUS-Government-Public-Domainfreenonemonthly (plus year-to-date and annual releases)yesmcp-needed-low-valueFIPSDATE
Census M3 (Manufacturers' Shipments, Inventories & Orders)US Census Bureau monthly survey of manufacturers' value of shipments, new orders, unfilled orders, and inventories, by NAICS-based industry category, served via the Economic Indicators time series API.government-open-datatime-seriesUS-Government-Public-Domainfreeapi-key-freemonthlyyesmcp-existsDATENAICS_CODE
CFTC Commitments of TradersWeekly breakdown of open interest in US futures and options markets by trader category, published by the CFTC.finance-marketstime-seriesUS-Government-Public-Domainfreenoneweeklyyesapi-direct-sufficientDATE
ChEMBLManually curated database of bioactive molecules with drug-like properties, integrating chemistry, bioactivity, and target/genomic data from medicinal chemistry literature and approved drugs.clinical-biotechregistryCC-BY-SA-3.0freenoneapproximately every 6-12 months (major releases); Release 37 May 2026yesmcp-needed-high-valueCHEMBL_IDUNIPROT_ACCESSIONDOIPMIDMESH_TERM
Chinese Clinical Trial Registry (ChiCTR)WHO ICTRP primary clinical trial registry for mainland China, recording interventional, prevention, diagnostic, prognostic, and epidemiological studies, run by the Chinese Clinical Trial Registry centre at West China Hospital, Sichuan University.clinical-biotechregistryunknownfreenonecontinuousnomcp-existsnpx -y chictr-mcp-server@latestWHO_UTN
ClinGen (Clinical Genome Resource)NIH-funded expert-curated resource defining the clinical relevance of genes and variants, covering gene-disease validity, dosage sensitivity, variant pathogenicity, and clinical actionability, plus a canonical allele registry.bio-genomicsknowledge-graphCC0freenonecontinuous expert curation; downloads refreshed as curations are publishedyesmcp-needed-high-valueRSIDGENE_SYMBOLENTREZ_GENE_IDEFO_ID
Clinical Research Information Service (CRIS)WHO- and ICMJE-recognised primary clinical trial registry for the Republic of Korea, operated by the Korea Disease Control and Prevention Agency, exposing Korean and English trial records via a web UI and a public-data-portal REST API.clinical-biotechregistryKOGL-Type-2free-non-commercialapi-key-freecontinuousnomcp-needed-low-valueWHO_UTN
Clinical Trial Outcomes (CTO)Large-scale benchmark of clinical trial outcomes with machine-generated and human-annotated success/failure labels, keyed on NCT ID.clinical-biotechregistryMITfreenoneperiodic (irregular releases; last refreshed 2025-10)yesmcp-needed-low-valueNCT_ID
Clinical Trials Registry - India (CTRI)WHO- and ICMJE-recognised primary clinical trials registry for studies conducted in India, run by ICMR, with mandatory prospective registration since 2009.clinical-biotechregistryunknownfreenonecontinuousnorequires-scrapingWHO_UTN
ClinicalTrials.govUS federal registry and results database of publicly and privately supported clinical studies conducted globally, run by the National Library of Medicine.clinical-biotechregistryUS-Government-Public-Domainfreenonedailyyesmcp-existsuvx --from biomcp-python biomcp runNCT_IDEUDRACT_NUMBEREU_CT_NUMBERPMIDMESH_TERM
ClinVarNIH/NCBI public archive of human genetic variants and their clinically asserted relationships to diseases and drug responses, with submitter evidence and a review-status confidence rating.bio-genomicsregistryUS-Government-Public-Domainfreenoneweekly XML release; monthly XML/VCF/TSV archives; some TSV summaries dailyyesapi-direct-sufficientRSIDGENE_SYMBOLENTREZ_GENE_IDMESH_TERM
CMS Medicare Part D PrescribersCMS annual summary of prescription drugs prescribed to Original Medicare Part D beneficiaries, aggregated at three grains (by provider NPI, by provider and drug, by geography and drug) with claim counts, day supply, drug cost, and beneficiary counts.healthcare-claimspanelUS-Government-Public-Domainfreenoneannualyesmcp-existsNPIFIPSUS_STATE_CODE
CMS Open PaymentsUS federal registry of payments and transfers of value from drug and medical device manufacturers and GPOs to physicians, non-physician practitioners, and teaching hospitals.healthcare-claimsmixedUS-Government-Public-Domainfreenoneannualyesmcp-needed-high-valueNPINDCUS_STATE_CODE
CommodityPriceAPICommercial REST API for real-time and historical prices on 130+ commodities (precious metals, energy, agricultural, soft commodities) with quote-currency conversion across 175+ currencies and daily history back to 1990.finance-marketstime-seriesCommodityPriceAPI-Proprietaryfreemiumapi-key-free60-second refresh on Plus and Premium; 10-minute delay on Lite. Monthly-only commodities deliver closing rate only.nomcp-needed-low-valueDATEISO_4217
Common CrawlFree open repository of monthly web crawls (300B+ pages, 15 years) with raw HTML, metadata, and extracted plaintext available as bulk WARC/WAT/WET files plus a CDX URL index.news-eventscorpusCommon-Crawl-Terms-of-Usefreenonemonthlyyesmcp-existsURLDATE
Companies House (UK)UK statutory register of incorporated companies with profiles, officers, filing history, and persons with significant control.corporate-registryregistryOGL-3.0freeapi-key-freereal-time for filings, monthly for bulk snapshotyesmcp-needed-high-valueCOMPANIES_HOUSE_NUMBERISO_3DATEURL
CORDIS (EU Research Projects)The European Commission's registry of EU-funded research projects (FP1 to Horizon Europe) with participating organisations, results, deliverables, and links to open-access publications.government-open-dataknowledge-graphCC-BY-4.0freenoneportal updated continuously; per-framework-programme bulk snapshots refreshed periodicallyyesmcp-needed-low-valueDOIISO_2
COREWorld's largest aggregator of open access research papers, harvesting metadata and full text from thousands of repositories and journals globally.academiccorpusODC-BYfreemiumapi-key-freecontinuousyesmcp-existsnpx -y @futurelab-studio/latest-science-mcp@latestDOIARXIV_IDPMIDISSNURL
CrossrefDOI registration agency and open metadata API for scholarly works, covering ~180M records deposited by member publishers across journals, books, conference proceedings, preprints, and datasets.academicregistryCC0freenonecontinuous (REST API); annual public data file snapshotyesmcp-existsDOIISSNORCIDROR
CT-ADECurated benchmark dataset of drug-adverse-event pairs extracted from ClinicalTrials.gov monopharmacy trial results, annotated to MedDRA SOC and PT levels for multilabel ADE prediction.clinical-biotechcorpusMITfreenonestaticyesmcp-needed-low-valueNCT_IDMEDDRA_TERMATC_CODECHEMBL_IDDRUGBANK_ID
CTG-DB (ClinicalTrials.gov MedDRA-Normalised Safety Database)Open-source pipeline that transforms the full ClinicalTrials.gov XML archive into a relational database with arm-level adverse-event counts normalised to MedDRA terminology.clinical-biotechregistryApache-2.0freenoneone-off snapshot (input archive downloaded 2026-02-10); no automatic refreshnomcp-needed-low-valueNCT_IDMEDDRA_TERM
CZ CELLxGENE DiscoverChan Zuckerberg Initiative platform hosting standardized single-cell RNA-seq datasets plus the aggregated Census, a queryable cell-by-gene expression corpus with ontology-normalized cell, tissue, and assay metadata.bio-genomicspanelCC-BY-4.0freenoneportal: continuous dataset ingestion; Census: weekly latest build + ~6-monthly long-term-support releasesyesmcp-needed-high-valueENSEMBL_IDUBERON_IDEFO_IDNCBI_TAXON_IDDOI
DailyMedNLM's authoritative repository of FDA-submitted Structured Product Labels (SPLs) for prescription, OTC, homeopathic, animal, and other regulated drug products in the US.clinical-biotechregistryUS-Government-Public-Domainfreenonedaily, weekly, and monthly delta archives; full snapshots refreshed periodicallyyesmcp-existsNDCRXNORM_CUI
DataCiteGlobal DOI registration agency and metadata graph for research datasets, software, preprints, and other non-article research outputs.academicregistryCC0freenonecontinuous (API); annual snapshot (Public Data File)yesmcp-existsDOIORCIDRORFUNDER_DOIURL
dbSNPNIH/NCBI public archive of short genetic variation (SNVs, short indels, microsatellites) keyed to RefSNP (rs) clusters, with mapped coordinates, allele frequencies, and cross-references to genes and clinical resources.bio-genomicsregistryUS-Government-Public-Domainfreenoneperiodic builds (Build 157 released 2025-03-18); ALFA allele-frequency updates quarterlyyesapi-direct-sufficientRSIDGENE_SYMBOLENTREZ_GENE_ID
DefiLlama StablecoinsOpen API tracking circulating supply, chain distribution, peg mechanism, and historical market cap of stablecoins across every supported blockchain, run as the stablecoins module of the DefiLlama TVL aggregator.finance-marketstime-seriesDefiLlama-Termsfreemiumnonecirculating supply refreshed hourly per chain; historical mcap and price series updated dailynomcp-needed-high-valueDATEISO_4217
DepMap (Cancer Dependency Map)Genome-wide CRISPR (Chronos) and RNAi (DEMETER2) loss-of-function screens plus PRISM drug screens across ~1,100 cancer cell lines, giving per-gene dependency (gene-effect) scores; the functional-dependency layer over CCLE's molecular characterisation, hosted on the Broad Institute's DepMap Portal.bio-genomicspanelDepMap-Terms-Of-Usefree-non-commercialnonebi-annual releases (e.g. 25Q2, 25Q4, 26Q1)yesmcp-existsGENE_SYMBOLENSEMBL_IDENTREZ_GENE_ID
DrugBankCurated drug knowledgebase covering chemistry, pharmacology, targets, interactions, and external identifiers for approved, investigational, and experimental small-molecule and biotech drugs.clinical-biotechregistryDrugBank-Custom-Licensefree-non-commercialaccount-requiredminor releases every few months; major versions ~yearlyyesmcp-existsCHEMBL_IDRXNORM_CUIBNF_CODEGENE_SYMBOLUNIPROT_ACCESSIONMESH_TERMWIKIDATA_QID
DrugCentralOpen online drug compendium of approved and off-market drugs linking structures, mechanism-of-action targets, indications, ATC classes, FAERS signals, and a dense external-identifier crosswalk.clinical-biotechknowledge-graphCC-BY-SA-4.0freenoneroughly biennial major releases; latest dump 2023-11-01yesmcp-needed-high-valueINCHI_KEYCHEMBL_IDDRUGBANK_IDUNIIRXNORM_CUICHEBI_IDATC_CODENDCMEDDRA_TERMUNIPROT_ACCESSIONGENE_SYMBOL
DrugCombOpen-access portal of harmonized cancer drug-combination and single-drug screening data, reporting CSS sensitivity plus Loewe, Bliss, HSA, and ZIP synergy scores per drug-drug-cell-line experiment across dozens of studies.clinical-biotechpanelunknownfreenoneperiodic versioned releases (data files v1.3-v1.5); update paper snapshot March 2021yesmcp-needed-high-valueCHEMBL_IDDRUGBANK_IDINCHI_KEY
Drugs@FDAFDA's authoritative record of approved drug and biologic products, with full application, product, and submission/supplement approval history plus links to approval letters, labels, and review documents.clinical-biotechregistryCC0freeapi-key-freedaily (Monday-Friday) on the openFDA mirror; raw FDA data files refreshed regularlyyesmcp-needed-high-valueFDA_APPLICATION_NUMBERNDCUNII
E-PRTR (European Industrial Emissions Portal)EU-wide register of pollutant releases, waste transfers, and energy/emissions data for ~33,000 large industrial facilities across 33 European countries.government-open-datamixedCC-BY-4.0freenoneannualyesmcp-needed-low-valueISO_2NUTSDATE
ECB Data Portal (SDMX API)European Central Bank statistical warehouse (exchange rates, interest rates, monetary aggregates, balance of payments) served as time series via an SDMX 2.1 REST API.finance-marketstime-seriesESCB-Free-Reusefreenonevaries by dataflow (daily for EXR to quarterly for BOP/GFS)yesmcp-needed-high-valueISO_4217ISO_2DATE
ECMWF (European Centre for Medium-Range Weather Forecasts)Global numerical weather forecasts, ensemble products, and the ERA5 climate reanalysis from ECMWF, distributed via the free ECMWF Open Data feed, the Copernicus Climate Data Store API, and the licensed MARS archive.geospatialmixedCC-BY-4.0freemiumapi-key-freeoperational forecasts run 2-4x daily; ERA5 updated ~daily with lag; monthly and seasonal productsyesmcp-needed-low-valueDATE
EIA Open DataUS Energy Information Administration's REST API and bulk files covering energy production, consumption, prices, and forecasts across electricity, petroleum, natural gas, coal, nuclear, and international markets.finance-marketsmixedUS-Government-Public-Domainfreeapi-key-freetwice-daily for most series; weekly/monthly/annual underlying cadence varies by routeyesmcp-needed-low-valueDATEISO_3US_STATE_CODE
EMA EPAR / MedicinesThe European Medicines Agency's public register of centrally authorised human and veterinary medicines, with regulatory status, active substance, ATC code, therapeutic area, marketing-authorisation timeline, and links to European Public Assessment Reports (EPARs).clinical-biotechregistryEC-Reuse-Notice-2011-833freenonedaily (tables refreshed overnight; JSON report regenerated up to twice daily)yesmcp-existsnode build/index.js (clone github.com/openpharma-org/ema-mcp, then npm install && npm run build)ATC_CODEMESH_TERM
EMPIARPublic archive of raw image data underpinning 3D electron microscopy structures (cryo-EM single particle, cryo-electron tomography, volume EM), run by EMBL-EBI as a companion to EMDB.bio-genomicscorpusCC0-1.0freenonecontinuous deposition tied to EMDB submissions; new entries released on author-set datesyesmcp-needed-low-valuePDB_IDNCBI_TAXON_ID
ENCODEEncyclopedia of DNA Elements — international consortium portal of functional genomics experiments (ChIP-seq, RNA-seq, ATAC-seq, DNase, methylation) across human and mouse, with a REST API over experiments, files, biosamples, and candidate regulatory elements.bio-genomicsregistryCC-BY-4.0freenonerolling; periodic named data releasesyesmcp-needed-high-valueENSEMBL_IDUBERON_IDDOI
EnsemblOpen genome annotation project from EMBL-EBI covering 4,700+ genomes with REST API, BioMart, FTP downloads, and MySQL access.bio-genomicsknowledge-graphApache-2.0freenonequarterlyyesmcp-existsENSEMBL_IDGENE_SYMBOLUNIPROT_ACCESSION
EPA ECHO (Enforcement & Compliance History Online)US EPA integrated compliance, enforcement, inspection, and permit-discharge database for ~800,000 facilities regulated under the Clean Air Act, Clean Water Act, RCRA, and SDWA.government-open-datamixedUS-Government-Public-Domainfreenoneweeklyyesmcp-existsFIPSUS_STATE_CODEZCTANAICS_CODEEPA_REGISTRY_ID
EPA Facility Registry Service (FRS)US EPA master registry of facilities and sites subject to environmental regulation, each assigned a single cross-program FRS Registry ID.government-open-dataregistryUS-Government-Public-Domainfreenoneweeklyyesapi-direct-sufficientFIPSUS_STATE_CODEZCTANAICS_CODEEPA_REGISTRY_ID
EPO Open Patent Services (OPS)European Patent Office REST API for worldwide patent bibliographic, legal-status, full-text, image, family, and classification data.government-open-dataregistryEPO-OPS-Fair-Usefree-with-registrationoauthweeklynomcp-existsPATENT_PUBLICATION_NUMBERCPC_CODEINPADOC_FAMILY_ID
eQTL CatalogueUniformly reprocessed QTL summary statistics (eQTL, sQTL, and other molecular traits) across ~74 cell types and tissues, all on GRCh38.bio-genomicsmixedCC-BY-4.0freenoneirregular major releases; r8 pre-release Jan 2026, prior stable r7 Jun 2024yesmcp-needed-low-valueRSIDENSEMBL_IDEFO_IDGENE_SYMBOLUBERON_ID
EU Clinical Trials Register (EUCTR / EudraCT)Legacy public register of interventional clinical trials of medicines conducted in the EU and EEA between May 2004 and January 2025 under Directive 2001/20/EC, backed by the EudraCT database and run by the European Medicines Agency.clinical-biotechregistryEU-Commission-Reuse-Decision-2011-833freenonelegacynorequires-scrapingEUDRACT_NUMBERNCT_IDWHO_UTN
EU CTIS (Clinical Trials Information System)EU and EEA single-entry-point registry for clinical trials of human medicines under Regulation 536/2014, run by the European Medicines Agency in cooperation with member states and the European Commission.clinical-biotechregistryEU-Commission-Reuse-Decision-2011-833freenonecontinuousnomcp-needed-high-valueEU_CT_NUMBEREUDRACT_NUMBERWHO_UTN
Europe PMCOpen archive of life-sciences literature covering ~48M articles, preprints, and full-text open-access biomedical papers, mirrored from PubMed Central with European deposit and funder linkage.academiccorpusCC-BY-4.0freenoneweeklyyesmcp-existsnpx -y @futurelab-studio/latest-science-mcp@latestDOIPMIDPMCIDORCIDRORISSNMESH_TERMCHEMBL_IDUNIPROT_ACCESSIONENSEMBL_ID
European Nucleotide Archive (ENA)EMBL-EBI's open archive of nucleotide sequence and raw read data; the European INSDC node mirroring NCBI SRA and DDBJ.bio-genomicscorpusEMBL-EBI-Terms-of-Usefreenonecontinuousyesmcp-needed-high-valueNCBI_TAXON_ID
Eurostat PRODCOMEU statistics on the physical and value volume of manufactured goods sold, exported, and imported, by 8-digit product code, country, and year.government-open-datapanelCC-BY-4.0freenoneannualyesmcp-existsuv --directory /path/to/eurostat-mcp run server.pyISO_2DATE
Event RegistryCommercial news intelligence platform that ingests 150K+ global news sources in 60+ languages, clusters articles into events, and enriches with Wikidata-linked entities, sentiment, and categories.news-eventsevent-streamproprietary-no-redistributionfreemiumapi-key-freecontinuousnomcp-needed-low-valueWIKIDATA_QIDISO_2URLDATE
Expression Atlas (EMBL-EBI)Curated, uniformly re-analyzed gene and protein expression data across species, covering baseline (TPM by tissue/condition) and differential (log2FC, FDR) experiments, with a separate Single Cell Expression Atlas.bio-genomicsreference-tableCC-BY-4.0freenoneperiodic curated releases (data re-quantified against fixed Ensembl/Ensembl Genomes/EFO versions per release)yesmcp-needed-low-valueENSEMBL_IDGENE_SYMBOLEFO_IDNCBI_TAXON_IDPMID
FAA Aviation System Performance Metrics (ASPM)FAA online system reporting flight, delay, taxi-time, and airport-efficiency metrics for ~77 US ASPM airports and ~40 major ASPM carriers.government-open-datapanelUS-Government-Public-Domainfree-with-registrationaccount-requireddailynorequires-scrapingDATE
FactSet Fundamentals APIStandardised company financials, derived ratios, and business/geographic segment data for global public companies, addressed by market identifier.finance-marketspanelproprietarypaidapi-key-paiddaily updates as filings are processedyesmcp-needed-low-valueTICKERISINCUSIPFIGISEDOL
FDA Adverse Event Reporting System (FAERS)US FDA post-market pharmacovigilance database of spontaneous adverse-event and medication-error reports for drugs and therapeutic biologics, published as quarterly case-level extract files.clinical-biotechevent-streamUS-Government-Public-Domainfreenonequarterlyyesmcp-needed-low-valueMEDDRA_TERMFDA_APPLICATION_NUMBER
FDA MAUDE (Device Adverse Events)US FDA Manufacturer and User Facility Device Experience database of medical-device adverse-event reports (malfunctions, injuries, deaths), reachable via the CDRH MAUDE web search and the openFDA device/event REST API and bulk JSON.clinical-biotechevent-streamCC0freeapi-key-freeweeklyyesmcp-exists
FDA Medical Device DatabasesUS FDA medical-device authorizations and post-market safety data via openFDA device endpoints and the CDRH databases, covering 510(k) clearances, PMA approvals, De Novo, classification, recalls/enforcement, MAUDE adverse events, and UDI.clinical-biotechregistryCC0freeapi-key-freeweekly for most device endpoints; CDRH web databases refreshed on similar cadenceyesmcp-exists
FDA Orange BookFDA's Approved Drug Products with Therapeutic Equivalence Evaluations, the canonical US source for approved drug products, therapeutic equivalence (TE) codes, listed patents, and marketing exclusivity periods.clinical-biotechregistryUS-Government-Public-Domainfreenonemonthlyyesmcp-needed-high-valueNDC
FDA Purple BookFDA database of all US-licensed biological products (including biosimilars and interchangeables) with BLA numbers, reference-product relationships, exclusivity dates, and patent listings.clinical-biotechregistryUS-Government-Public-Domainfreenonemonthlyyesmcp-needed-low-value
Federal Reserve G.17 Industrial Production and Capacity UtilizationMonthly Federal Reserve Board indexes of US industrial production, capacity, and capacity utilization for manufacturing, mining, and electric and gas utilities, broken out by market group and NAICS industry.finance-marketspanelUS-Government-Public-Domainfreenonemonthlyyesmcp-needed-low-valueDATENAICS_CODE
Financial Modeling PrepCommercial financial-data API covering company fundamentals, financial statements, real-time and historical prices, ETFs, forex, crypto, commodities, and macro-economic series.finance-marketsmixedproprietaryfreemiumapi-key-freereal-time to daily depending on plan and endpointyesmcp-existsnpx financial-modeling-prep-mcp-server --fmp-token=$FMP_API_KEYTICKERCIKISINCUSIPISO_4217DATE
Finnhub Stock APIMulti-asset market data API covering global equities, FX, crypto, company fundamentals, estimates, alternative data, and economic indicators behind a single REST endpoint plus WebSocket streaming, with a generous free tier the provider markets as real-time.finance-marketstime-seriesFinnhub-Terms-of-Servicefreemiumapi-key-freereal-time on US equities (free) and global equities on premium; intraday and daily candlesnomcp-existsTICKERISINCUSIPFIGICIKLEIISO_3ISO_4217DATE
FINRA Equity Short InterestBi-monthly consolidated short interest positions FINRA collects for all exchange-listed and OTC equity securities under Rule 4560.finance-marketspanelFINRA-Data-Termsfree-non-commercialnonetwice monthly (mid-month and end-of-month settlement dates)yesmcp-existsTICKERDATE
FINRA TRACE (Trade Reporting and Compliance Engine)OTC secondary-market transaction data for US fixed income (corporate, agency, treasury, and securitized products) reported to FINRA TRACE, plus aggregate volume and market-breadth datasets.finance-marketsevent-streamFINRA-Fixed-Income-Data-Termsfreemiumoauthreal-time trade dissemination; end-of-day, weekly, and monthly aggregate datasetsyesmcp-existsCUSIPFIGIDATE
FRED (Federal Reserve Economic Data)Aggregated economic and financial time-series database (~800K series) maintained by the Federal Reserve Bank of St. Louis, covering US macro indicators plus international data from BIS, OECD, World Bank, and others.finance-marketstime-seriesFRED-Mixed-Source-Termsfreeapi-key-freevaries by series (daily, weekly, monthly, quarterly, annual)yesmcp-existsDATEISO_3
GDELT (Global Database of Events, Language, and Tone)Open real-time event database extracting people, organizations, locations, themes, and tone from global news media in 100+ languages.news-eventsevent-streamGDELT-Open-Datafreenoneevery 15 minutesyesmcp-needed-high-valueISO_3DATEURLWIKIDATA_QID
GDSC (Genomics of Drug Sensitivity in Cancer)Drug-sensitivity screen of ~400 anti-cancer compounds against ~1,000 genetically characterised human cancer cell lines, reporting ln(IC50), AUC, and Z-score per cell-line/compound pair, integrated with COSMIC genomic features.clinical-biotechpanelGDSC-Terms-Of-Usefreenoneperiodic major releases (release-8.x); current_release drop dated 24Jul22 (v8.4), later drop v8.5 dated Oct 2023 on the cog object storeyesmcp-needed-high-valueCHEMBL_IDGENE_SYMBOL
Gene OntologyCanonical open ontology of gene functions (molecular function, biological process, cellular component) plus curated GO annotations linking genes and gene products to GO terms across hundreds of species.bio-genomicsknowledge-graphCC-BY-4.0freenonemonthlyyesmcp-existsGO_IDUNIPROT_ACCESSIONENSEMBL_IDGENE_SYMBOLENTREZ_GENE_IDNCBI_TAXON_IDPMIDDOI
GLEIF LEIGlobal register of Legal Entity Identifiers (ISO 17442) for legal entities, with reference data, corporate-ownership relationships, and BIC/ISIN/MIC cross-mappings.corporate-registryregistryCC0freenoneGolden Copy three times daily; ISIN-to-LEI mapping daily; BIC-to-LEI mapping monthlyyesmcp-existsLEIISINISO_2DATE
Global Biodiversity Information Facility (GBIF)International network and integrated infrastructure aggregating species occurrence records, taxonomic backbone, datasets, and publishing organisations from thousands of natural-history collections, surveys, and citizen-science feeds, each occurrence carrying lat/lon, eventDate, taxonomic keys, and Darwin Core fields.geospatialmixedCC-BY-4.0freenoneContinuous ingestion from publishers; species backbone rebuilt periodically (months); occurrence index updated as datasets are re-crawledyesmcp-existsNCBI_TAXON_IDWIKIDATA_QIDDOIORCIDISO_3ISO_2DATE
gnomAD (Genome Aggregation Database)Population-scale reference of human allele frequencies aggregated from hundreds of thousands of exomes and genomes, used to gauge how common a variant is in the general population.bio-genomicsreference-tableMITfreenoneapproximately annual major releases; v4.1 released 2024-04-19yesmcp-needed-high-valueRSIDENSEMBL_IDGENE_SYMBOL
GNPSOpen community knowledge base of tandem MS/MS reference spectra, molecular networks, and natural-product annotations, run by the Dorrestein lab / CCMS at UC San Diego.bio-genomicsknowledge-graphCC0freenonecontinuous (community contributions)yesmcp-needed-low-valueINCHI_KEYPMID
Google Patents Public Datasets (BigQuery)BigQuery collection of worldwide patent bibliographic data (90M+ publications from 17 countries) plus research-layer enrichments, queryable in SQL.government-open-dataregistryCC-BY-4.0freemiumaccount-requiredquarterlyyesmcp-needed-low-valuePATENT_PUBLICATION_NUMBERCPC_CODE
Google TrendsGoogle's public search-interest explorer, exposing normalised relative-search-volume time series and geographic breakdowns for any query, topic, or category back to 2004.consumer-signaltime-seriesGoogle-Terms-Of-Servicefreenonedailynofragile-unofficialDATEISO_2ISO_3WIKIDATA_QID
GTEx (Genotype-Tissue Expression)Reference atlas of tissue-specific gene expression and genetic regulation (eQTL/sQTL) across ~54 human tissues from ~1000 post-mortem donors.bio-genomicspanelGTEx-Open-Accessfreenoneper-releaseyesmcp-needed-low-valueGENE_SYMBOLENSEMBL_ID
GWAS CatalogNHGRI-EBI curated catalogue of published genome-wide association studies, variant-trait associations, study metadata, and full summary statistics where available.bio-genomicsregistryEMBL-EBI-Terms-of-Usefreenoneapproximately weekly catalogue release; summary-statistics ingest is continuousyesmcp-existsPMIDDOIGENE_SYMBOLENSEMBL_IDEFO_ID
Hacker News APIOfficial Hacker News API exposing every story, comment, job post, Ask HN, Show HN, poll, and user profile as JSON via Firebase, with live update feeds and walk-the-entire-corpus access from item 1.consumer-signalcorpusMITfreenonereal-timenomcp-existsURLDATE
Harmonized System CodesHierarchical lookup of the World Customs Organization Harmonized System (HS) classification, mirrored as public-domain CSV on DataHub from the UN Comtrade nomenclature endpoint.government-open-datareference-tableODC-PDDL-1.0freenoneirregularyesmcp-needed-low-value
HMDB (Human Metabolome Database)Curated knowledgebase of small-molecule human metabolites with chemical, clinical, and biochemical annotation cross-linked to major chemistry and biology databases.bio-genomicsknowledge-graphCC-BY-NC-4.0free-non-commercialnoneirregularyesmcp-existsnpx mcp-remote https://hmdb-mcp-server.quentincody.workers.dev/mcpCHEBI_IDINCHI_KEYDRUGBANK_IDUNIPROT_ACCESSIONGENE_SYMBOLHMDB_ID
HuBMAP Data PortalNIH Human BioMolecular Atlas Program portal of multi-modal spatial and single-cell datasets from healthy human tissue, with donor/sample/dataset provenance.bio-genomicsregistryCC-BY-4.0freenonecontinuous (new datasets published on a rolling basis)nomcp-needed-low-valueUBERON_IDDOI
Human Cell Atlas Data PortalOpen portal aggregating community-contributed single-cell and multi-omic datasets, with a faceted metadata API over projects, donors, samples, and files plus downloadable expression matrices.bio-genomicsregistryCC-BY-4.0freenonerolling; new DCP catalog snapshots (dcp59, dcp60, ...) released periodicallyyesmcp-needed-high-valueENSEMBL_IDUBERON_ID
Human Phenotype OntologyStandardised computable vocabulary of human phenotypic abnormalities, with curated annotations linking phenotype terms to hereditary diseases and disease genes.bio-genomicsknowledge-graphHPO-Licensefreenoneroughly monthly to quarterly release cadenceyesmcp-existsGENE_SYMBOLENTREZ_GENE_IDHPO_IDOMIM_ID
Human Protein AtlasOpen-access atlas of human protein expression across tissues, single cells, brain regions, cancers, and blood, integrating antibody-based imaging with transcriptomics and proteomics.bio-genomicsregistryCC-BY-4.0freenoneannual major release (currently v25.1, May 2026)yesmcp-needed-low-valueENSEMBL_IDUNIPROT_ACCESSIONGENE_SYMBOL
IBAN Country CodesHTML lookup table of ISO 3166-1 country codes (alpha-2, alpha-3, numeric) keyed by country name, republished by iban.com.government-open-datareference-tableiban-com-termsfreenoneirregularnomcp-needed-low-valueISO_2ISO_3
IBAN Currency CodesHTML lookup table of ISO 4217 currency codes (alphabetic and numeric) keyed by country/territory, republished by iban.com.government-open-datareference-tableiban-com-termsfreenoneirregularnomcp-needed-low-valueISO_4217
ICI Fund FlowsInvestment Company Institute weekly and monthly estimates of US mutual fund and ETF flows, money market fund assets, and related fund-industry statistics.finance-marketstime-seriesICI-Terms-of-Usefreenoneweekly (long-term flows, ETF flows, money market assets); monthly and quarterly for other seriesyesmcp-needed-low-valueDATE
IGSR (International Genome Sample Resource)EMBL-EBI hosted registry of open-consent human genome samples and population variant calls from the 1000 Genomes Project and successor collections (HGSVC, MAGE, ONT, Illumina Platinum).bio-genomicsregistryEMBL-EBI-Terms-of-Usefreenonecontinuousyesmcp-existsDOIPMID
Image Data Resource (IDR)Public repository of curated, richly annotated reference bioimaging datasets from published scientific studies, served on OMERO with a session-based JSON API, search engine, and bulk download.bio-genomicscorpusCC-BY-4.0freeaccount-requiredrolling; new studies curated and added on an ongoing basisyesmcp-needed-low-valueNCBI_TAXON_IDGENE_SYMBOLPDB_ID
IMF DataThe IMF's official statistics portal, macroeconomic and financial time series across datasets like IFS, Balance of Payments, Direction of Trade, Government Finance, CPI, and Financial Soundness, served over an SDMX 2.1 / 3.0 REST API.government-open-datamixedIMF-Data-Termsfreenonevaries by dataset (monthly, quarterly, annual)yesmcp-existsISO_2ISO_3ISO_4217DATE
InterProIntegrated database of protein families, domains, and functional sites maintained by EMBL-EBI, unifying signatures from 13 member databases (Pfam, CATH-Gene3D, PANTHER, PROSITE, SMART, and others) into a single resource with REST API and FTP bulk downloads.bio-genomicsregistryCC0freenoneapproximately every 8 weeks (~2 months); release 109.0 June 2026yesmcp-needed-high-valueINTERPRO_IDUNIPROT_ACCESSIONPDB_IDGO_IDNCBI_TAXON_ID
ISRCTN RegistryWHO- and ICMJE-recognised primary clinical study registry for interventional and non-interventional studies, focused on studies involving UK participants but open to global registration, run by BioMed Central (Springer Nature).clinical-biotechregistryCC0freenonecontinuousyesmcp-needed-high-valueNCT_IDWHO_UTNEUDRACT_NUMBERDOI
IUPHAR/BPS Guide to PHARMACOLOGYExpert-curated database of quantitative drug-target interactions, linking pharmacological targets (receptors, ion channels, enzymes, transporters) to ligands (approved drugs, tool compounds, endogenous molecules).clinical-biotechknowledge-graphCC-BY-SA-4.0freenoneroughly triennial versioned releases (e.g. 2026.1, 2026.2)yesmcp-existsUNIPROT_ACCESSIONCHEMBL_IDENSEMBL_IDENTREZ_GENE_IDDRUGBANK_IDCHEBI_IDINCHI_KEY
Japan Registry of Clinical Trials (jRCT)Japan's national clinical-trial registry run by the Ministry of Health, Labour and Welfare, disclosing specified clinical trials and regenerative-medicine studies under the Clinical Trials Act; a WHO ICTRP primary registry that, together with the legacy UMIN-CTR, forms the Japan Primary Registries Network (JPRN).clinical-biotechregistryjRCT-Terms-of-Usefreenonecontinuousnorequires-scrapingWHO_UTN
KEGG (Kyoto Encyclopedia of Genes and Genomes)Integrated database of pathways, genes, compounds, reactions, diseases, and drugs maintained by Kanehisa Laboratories at Kyoto University.bio-genomicsknowledge-graphKEGG-Customfreemiumnonemonthlyyesmcp-existsGENE_SYMBOLENTREZ_GENE_IDUNIPROT_ACCESSIONENSEMBL_IDCHEBI_IDPMIDNCBI_TAXON_IDPDB_ID
Lens PatSeqBulk collection of DNA, RNA, and protein sequences disclosed in patent documents worldwide, with linked patent metadata, searchable by sequence similarity.government-open-datacorpusLens-PatSeq-Termsfree-non-commercialaccount-requiredyesmcp-needed-low-valuePATENT_PUBLICATION_NUMBERCPC_CODE
LINCS / CMap L1000 (CLUE)Perturbational gene-expression signatures from the Broad Institute's L1000 assay (>1M replicate-collapsed signatures over >5,000 compounds and genetic perturbations across a core panel of human cell lines), served through the CLUE platform, GEO, and Google BigQuery.bio-genomicspanelCLUE-Terms-Of-Usefree-non-commercialapi-key-freestatic major releases (GSE92742 Phase I 2017, GSE70138 Phase II, 2020 beta release); no rolling refreshyesmcp-needed-low-valueGENE_SYMBOLENTREZ_GENE_IDINCHI_KEY
LOINCInternational reference terminology that assigns unique codes to laboratory tests, clinical measurements, observations, and documents.clinical-biotechreference-tableLOINC-Licensefree-with-registrationaccount-requiredsemiannual major releases (v2.82 released 2026-02-24)yesmcp-needed-high-valueLOINC_CODESNOMED_CT_ID
MarineCadastre AIS Vessel TrafficUS Coast Guard Nationwide AIS vessel position broadcasts for US coastal and ocean waters, cleaned and republished as bulk CSV and GeoParquet by NOAA's MarineCadastre.geospatialevent-streamCC0freenoneannual bulk CSV; experimental daily/monthly GeoParquet for 2024-2025yesmcp-needed-low-valueDATE
MeSH (Medical Subject Headings)NLM's controlled, hierarchically-organized biomedical vocabulary used to index MEDLINE/PubMed and other NLM databases, published as annual XML/RDF and queryable via a SPARQL endpoint and Linked-Data URI service.academicknowledge-graphUS-Government-Public-Domainfreenoneannualyesmcp-needed-high-valueMESH_TERM
MetaboLightsEMBL-EBI open repository of metabolomics studies, raw and derived experimental data, metabolite structures, and reference spectra.bio-genomicsregistryCC0freenonecontinuousyesmcp-needed-high-valueCHEBI_IDPMIDDOIHMDB_ID
Mondo Disease OntologyOpen disease ontology that harmonises disease definitions across OMIM, Orphanet, DOID, EFO, ICD, MeSH, NCIt and more via precise equivalence axioms, minting a single canonical MONDO id per disease concept.bio-genomicsknowledge-graphCC-BY-4.0freenonemonthlyyesmcp-existsuvx ols-mcp-server (wraps EBI OLS4; ontologyId=mondo)EFO_IDICD_10MESH_TERMMEDDRA_TERMMONDO_IDOMIM_IDORPHA_CODE
MusicBrainz APICommunity-maintained open music metadata database for artists, releases, recordings, works, labels, and places, exposed via REST API and full PostgreSQL bulk dumps.consumer-signalknowledge-graphCC0free-non-commercialnoneweeklyyesmcp-existsISNIISO_2WIKIDATA_QIDURL
MyVariant.infoBioThings API aggregating genetic-variant annotations from dozens of sources (dbSNP, ClinVar, dbNSFP, CADD, and more) behind one fast REST query interface keyed on variants.bio-genomicsknowledge-graphBioThings-Aggregate-Termsfreenoneweekly annotation refreshyesmcp-existsuvx --from biomcp-python biomcp runRSIDGENE_SYMBOLENTREZ_GENE_ID
Nasdaq Data LinkNasdaq-operated marketplace and REST API delivering financial, economic, and alternative time-series and tables data (formerly Quandl), spanning free public-domain datasets and ~400+ premium vendor databases.finance-marketsmixednasdaq-data-link-mixed-vendor-termsfreemiumapi-key-freevaries by dataset (intraday, daily, weekly, monthly, quarterly, annual)yesmcp-existsTICKERISINCUSIPISO_3DATE
Nasdaq Trader Symbol DirectoryAuthoritative directory of Nasdaq-listed and other US exchange-listed securities published daily as pipe-delimited files by Nasdaq Trader.finance-marketsregistrynasdaqtrader-symbol-directory-no-published-termsfreenonemultiple times per trading dayyesmcp-needed-low-valueTICKER
NCBI GeneNIH-maintained reference database of gene-specific information across all sequenced species, with nomenclature, sequences, maps, pathways, and cross-references.bio-genomicsregistryUS-Government-Public-Domainfreeapi-key-freedailyyesmcp-existsGENE_SYMBOLENSEMBL_IDPMIDMESH_TERM
NCBI GEONIH/NCBI Gene Expression Omnibus, public repository of microarray, RNA-seq, and other high-throughput functional genomics data with 286k+ series and 8.5M+ samples.bio-genomicsregistryUS-Government-Public-Domainfreenonedailyyesmcp-existsPMIDGENE_SYMBOLMESH_TERM
NCBI ProteinNIH-maintained protein sequence database aggregating records from RefSeq, GenBank/EMBL/DDBJ translated CDS, SwissProt, PIR, PRF, and PDB into one Entrez-queryable surface.bio-genomicsregistryUS-Government-Public-Domainfreeapi-key-freedailyyesmcp-existsUNIPROT_ACCESSIONPDB_IDPMIDNCBI_TAXON_ID
NCBI SRA (Sequence Read Archive)Largest public repository of high-throughput raw sequencing reads and alignment metadata, run by NCBI/NLM/NIH.bio-genomicsregistryUS-Government-Public-Domainfreeapi-key-freecontinuousyesmcp-existsPMIDPMCIDDOIMESH_TERM
NCBI TaxonomyNCBI-curated classification and nomenclature for every organism represented in the public sequence databases, with a stable integer taxon ID linking nucleotide, protein, gene, assembly, BioSample, and PubMed records across NCBI and downstream resources.bio-genomicsknowledge-graphUS-Government-Public-Domainfreeapi-key-freedailyyesmcp-existsNCBI_TAXON_IDPMID
NCI Genomic Data Commons (GDC)NCI's unified repository of harmonised cancer genomic, clinical, and biospecimen data spanning TCGA, TARGET, CPTAC, MMRF, HCMI, and 30+ other programs, with a single REST API and bulk transfer tool.bio-genomicsregistryUS-Government-Public-Domainfreedars-or-equivalentcontinuousyesmcp-needed-high-valueENSEMBL_IDGENE_SYMBOLENTREZ_GENE_IDICD_10DOI
NewsAPICommercial REST API aggregating current and historic news articles from 150,000+ global publisher sources across 55 countries and 14 languages.news-eventsevent-streamproprietary-newsapi-tosfreemiumapi-key-freecontinuousnomcp-needed-low-valueURLDATE
NHGRI DNA Sequencing CostsNHGRI-tracked annual cost-per-genome and cost-per-megabase data for human DNA sequencing at NIH-funded genome sequencing centers, 2001 to 2022.bio-genomicstime-seriesUS-Government-Public-Domainfreenoneirregular; NHGRI states plans to update on a regular basis. Most recent table dated May 2022, page last updated May 2023.yesapi-direct-sufficientDATE
NHS Prescription Cost Analysis (PCA)NHSBSA monthly count of items dispensed and net ingredient cost for every drug, dressing, appliance, and medical device reimbursed by the NHS in community pharmacies in England, broken down by BNF code and NHS region.healthcare-claimstime-seriesOGL-3.0freenonemonthlyyesmcp-needed-low-valueBNF_CODEDATE
NIH RePORTERUS NIH database of federally funded biomedical research projects, their investigators, awarding institutes, funding amounts, and linked publications.government-open-dataregistryUS-Government-Public-Domainfreenoneweeklyyesmcp-existsPMIDUS_STATE_CODE
NPPES NPI RegistryPublic registry of every US healthcare provider's National Provider Identifier (NPI), with taxonomy, practice addresses, and other identifiers.healthcare-claimsregistryUS-Government-Public-Domainfreenoneweekly (bulk dissemination); full-replacement file monthly, incremental weeklyyesmcp-existsnpx -y npi-registry-mcp-serverNPIZCTAUS_STATE_CODE
OCC Options Volume & Open InterestDaily and historical US listed-options and futures volume, open interest, put/call ratios, and option series data from the Options Clearing Corporation, the central clearinghouse for all US-listed options.finance-marketstime-seriesOCC-Terms-of-Usefreenonedailyyesmcp-needed-low-valueTICKERDATE
OECD Data ExplorerOECD's flagship data portal exposing 1,500+ statistical dataflows across 38 member countries via a public SDMX 2.1 REST API, with CSV/Excel downloads and a browsable web UI.government-open-datamixedOECD-Terms-and-Conditionsfreenonevaries by dataflow (annual, quarterly, monthly)yesmcp-existsISO_3ISO_2ISO_4217
OMOP / OHDSI AthenaOHDSI's distribution point for the OMOP Standardized Vocabularies, a centralized crosswalk of 100+ medical terminologies (SNOMED, ICD-10, RxNorm, LOINC, NDC) mapped to standard OMOP concept IDs.clinical-biotechknowledge-graphmixed-vocabulary-licensesfree-with-registrationaccount-requiredquarterlyyesmcp-existsRXNORM_CUIICD_10NDCATC_CODEHCPCSCPTMESH_TERMMEDDRA_TERMOMOP_CONCEPT_IDSNOMED_CT_IDLOINC_CODE
OncoKBMSK's precision-oncology knowledge base of the clinical actionability of cancer gene alterations, mapping variants to oncogenic effect and FDA/guideline therapy levels.clinical-biotechknowledge-graphOncoKB-Termsfree-non-commercialapi-key-freerolling curation updates, versioned releasesyesmcp-existsuvx --from biomcp-python biomcp runGENE_SYMBOL
Open TargetsOpen-access drug target identification and prioritisation platform integrating genetics, genomics, transcriptomics, drugs, animal models, and scientific literature for target-disease association scoring.clinical-biotechknowledge-graphCC0-1.0freenonequarterlyyesmcp-existsENSEMBL_IDGENE_SYMBOLUNIPROT_ACCESSIONCHEMBL_IDEFO_IDDOIPMID
Open-MeteoFree weather, climate, marine, air-quality, and historical-reanalysis API aggregating 30+ national weather models (ECMWF, NOAA GFS, DWD ICON, JMA, MeteoFrance) at 1-11 km global resolution, queried by latitude/longitude with no API key.geospatialtime-seriesCC-BY-4.0free-non-commercialnoneforecast updated hourly to 6-hourly depending on model; ERA5 reanalysis updated daily with ~5 day lag; historical-forecast archive continuous since 2021nomcp-existsISO_2DATE
OpenAIRE GraphOpen scholarly knowledge graph linking research products (publications, data, software, other) to authors, organizations, funders, projects, and data sources across global research.academicknowledge-graphCC-BY-4.0freenoneversioned graph releases (~bi-monthly); API continuously updatedyesmcp-needed-high-valueDOIPMIDPMCIDARXIV_IDORCIDRORISNI
OpenAlexOpen scholarly knowledge graph covering papers, authors, institutions, concepts, topics, and citations across all of academia.academicknowledge-graphCC0freenonedailyyesmcp-existsnpx -y openalex-research-mcp (set OPENALEX_EMAIL)npx -y @futurelab-studio/latest-science-mcp@latestDOIPMIDPMCIDARXIV_IDORCIDRORISSNWIKIDATA_QIDMAG_ID
OpenCitationsOpen, CC0 infrastructure for scholarly citation and bibliographic metadata, exposing DOI-to-DOI citation links and document metadata via REST, SPARQL, and bulk dumps.academicknowledge-graphCC0freenoneperiodic releases (several times per year)yesmcp-needed-low-valueDOIPMIDORCIDISSNISBN
OpenCorporatesCross-jurisdiction database of legal entities sourced from 140+ official company registries worldwide.corporate-registryregistryODbL-1.0freemiumapi-key-freevaries by jurisdiction (real-time to monthly, mirrors source registry cadence)yesmcp-needed-high-valueCOMPANIES_HOUSE_NUMBERCIKISO_2ISO_3DATEURLWIKIDATA_QID
openFDAUS FDA Elasticsearch-backed public API and bulk downloads covering drug adverse events, product labeling, NDC directory, recalls, device safety reports, and food enforcement.clinical-biotechmixedCC0freeapi-key-freevaries by endpoint; many refreshed weekly, some dailyyesmcp-existsNDCRXNORM_CUIMEDDRA_TERMNCT_ID
OpenFIGIBloomberg-operated open mapping service that resolves third-party security identifiers (ISIN, CUSIP, SEDOL, ticker) to the Financial Instrument Global Identifier (FIGI) and back.finance-marketsregistryPublic-Domain-Dedicationfreeapi-key-freecontinuousnomcp-existsFIGIISINCUSIPSEDOLTICKER
OpenSky NetworkCrowdsourced ADS-B/Mode-S air traffic data — live aircraft state vectors and historical flight tracks from a global receiver network.geospatialevent-streamOpenSky-Data-Licensefree-non-commercialoauthreal-timeyesmcp-existsDATE
OpenStreetMapCrowdsourced global geographic database of roads, buildings, points of interest, boundaries, and natural features, with multiple read/write APIs and weekly planet dumps.geospatialgeospatialODbL-1.0freenonePlanet dump weekly (Fridays); daily/hourly/minutely diffs; Overpass minutely; Nominatim dailyyesmcp-needed-high-valueOSM_IDWIKIDATA_QIDWIKIPEDIA_ARTICLEISO_3ISO_2
OPRA Options FeedConsolidated real-time feed of quotes and last-sale reports for every US listed equity and index option, run by the Options Price Reporting Authority.finance-marketsevent-streamOPRA-Subscriber-Agreementpaidapi-key-paidreal-timenomcp-needed-low-valueTICKER
ORCIDGlobal registry of persistent researcher identifiers linking people to their works, affiliations, funding, and peer review activity.academicregistryCC0freenoneannualyesmcp-existsORCIDDOIRORWIKIDATA_QID
OrphanetReference knowledge base of rare diseases and orphan drugs, minting the ORPHAcode nomenclature and cross-referencing it to ICD-10/11, OMIM, MONDO, UMLS, MeSH, MedDRA, genes, and phenotypes.clinical-biotechknowledge-graphCC-BY-4.0freenoneOrphadata Science files bi-annual (Jul + Dec); nomenclature pack annual (Jul)yesmcp-needed-high-valueICD_10MESH_TERMMEDDRA_TERMGENE_SYMBOLENSEMBL_IDUNIPROT_ACCESSIONORPHA_CODEOMIM_IDUMLS_CUI
OSHA InspectionsUS OSHA workplace safety inspection, citation, and penalty records from the IMIS enforcement database, covering federal and state-plan inspections since 1972.government-open-dataevent-streamUS-Government-Public-Domainfreeapi-key-freequarterlyyesmcp-needed-low-valueUS_STATE_CODENAICS_CODE
Pan African Clinical Trials Registry (PACTR)WHO- and ICMJE-recognised primary clinical trials registry for trials conducted in Africa, the only African member of the WHO Network of Primary Registries, operated by the South African Medical Research Council (SAMRC).clinical-biotechregistryunknownfreenonecontinuousnorequires-scrapingWHO_UTN
PeptideAtlasCompendium of peptides and proteins identified from uniformly reprocessed public mass-spectrometry proteomics data, with protein-existence evidence and genome mappings; the Human build is the flagship.bio-genomicsknowledge-graphISB-PeptideAtlas-Termsfreenoneannual builds per organismyesmcp-needed-low-valueUNIPROT_ACCESSIONENSEMBL_IDGENE_SYMBOLPXD_IDENTIFIER
Personal Genome ProjectOpen-consent global network of participant-driven projects publishing whole-genome sequences, genotyping arrays, phenotype surveys, microbiome, and health records under a CC0-equivalent public-domain dedication.bio-genomicsregistryCC0-1.0freenoneirregularyesmcp-needed-low-valueURL
PharmGKBCurated pharmacogenomics knowledge base linking genes, variants, drugs, and diseases to drug-response phenotypes, clinical annotations, dosing guidelines, and annotated drug labels.bio-genomicsknowledge-graphCC-BY-SA-4.0freenoneyesmcp-needed-low-valueRSIDGENE_SYMBOLENSEMBL_IDENTREZ_GENE_IDUNIPROT_ACCESSIONRXNORM_CUIDRUGBANK_IDCHEBI_IDATC_CODENDCMESH_TERMNCT_IDPMIDPMCIDDOI
PhysioNet (MIMIC-IV / eICU)NIH-funded MIT repository of de-identified biomedical data whose flagship credentialed resources are the MIMIC-IV and eICU-CRD intensive-care EHR databases (diagnoses, labs, prescriptions, vitals, notes, waveforms).clinical-biotechmixedPhysioNet-Credentialed-Health-Data-License-1.5.0free-with-registrationdars-or-equivalentirregular; versioned releases (MIMIC-IV v3.1 released 2024-10-11)yesmcp-existsICD_10NDCLOINC_CODE
Polygon.ioMulti-asset market data API covering US stocks, options, indices, forex, crypto, and futures with REST, WebSocket, and S3 flat-file delivery.finance-marketstime-seriesPolygon-Terms-of-Servicefreemiumapi-key-freereal-time on paid tiers; 15-min delayed on free tieryesmcp-existsTICKERFIGIISINCUSIPCIKDATE
PredScope Prediction Market DataFree, no-auth REST API exposing live and resolved Polymarket prediction-market odds, volumes, and outcomes, refreshed every 10 minutes.finance-marketsevent-streampredscope-free-any-use-attribution-requestedfreenone10 minutesnomcp-needed-low-valueDATEURL
PRIDE ArchiveEMBL-EBI repository of mass-spectrometry proteomics datasets (raw + processed + identifications), the PRIDE member of the ProteomeXchange consortium.bio-genomicsregistryEMBL-EBI-Terms-of-Usefreenonecontinuous (new datasets published as they pass validation)yesmcp-existsDOIPMIDUNIPROT_ACCESSIONORCIDPXD_IDENTIFIER
PRISM Repurposing (Broad)PRISM multiplexed cell-line viability screen of ~4,500 repurposing compounds against ~580 human cancer cell lines, distributed by the Broad Institute's DepMap as bulk CSV on figshare.clinical-biotechpanelCC-BY-4.0freenoneperiodic DepMap releases (19Q3, 19Q4, 20Q2 primary/secondary, then Repurposing Public 23Q2, 24Q2); each release is staticyesmcp-needed-high-value
Proceedings of Machine Learning Research (PMLR)Open-access proceedings of machine learning conferences and workshops (ICML, AISTATS, CoRL, UAI, and many workshops), published as per-volume PDFs plus openly available BibTeX metadata without a conventional publisher.academiccorpusPMLR-Author-Copyrightfreenonerolling; a new volume is posted as each conference or workshop completesyesmcp-needed-low-valueURLISSN
Project Baseline Health StudyDeep-phenotyped longitudinal cohort of ~2,500 US adults followed 2017-2023 with annual clinical assessments, multi-organ imaging, continuous Verily Study Watch wearable data, labs, functional tests, and participant-reported outcomes. Access is request-gated through Verily's platform.public-healthpanelcontrolled-access-data-use-agreementfree-with-registrationaccount-requiredclosed cohort; enrolment and active follow-up ran 2017-2023, no new participant data addednorequires-scrapingNCT_ID
Project Data SphereFree digital library of de-identified, patient-level data from academic and industry Phase II-III oncology clinical trials.clinical-biotechcorpusPDS-Data-Sharing-Agreementfree-with-registrationaccount-requiredirregularyesmcp-needed-low-valueNCT_ID
ProteomeXchangeConsortium and central index coordinating proteomics data deposition across the main repositories, minting PXD dataset accessions and exposing dataset metadata through ProteomeCentral.bio-genomicsregistryProteomeXchange-Open-Datafreenonecontinuous; new datasets announced as they are made publicyesmcp-needed-low-valuePMIDDOIPXD_IDENTIFIER
PubChemOpen chemistry database from NIH/NLM aggregating compounds, substances, and bioassays with dense cross-references to drug, target, and literature resources.clinical-biotechknowledge-graphUS-Government-Public-Domainfreenonecompound and substance records updated continuously; FTP snapshots refreshed regularly (weekly for most subsets)yesmcp-existsINCHI_KEYCHEMBL_IDDRUGBANK_IDCHEBI_IDUNIIMESH_TERMPMIDDOIUNIPROT_ACCESSIONGENE_SYMBOLENTREZ_GENE_IDNCBI_TAXON_IDNDCATC_CODERXNORM_CUIWIKIDATA_QID
PubMed (NCBI E-utilities)NCBI's biomedical literature database (~37M citations from MEDLINE, life-science journals, and online books), exposed via the Entrez E-utilities REST API and annual XML bulk releases.academiccorpusUS-Government-Public-Domainfreeapi-key-freedailyyesmcp-existsuvx --from biomcp-python biomcp runnpx -y @futurelab-studio/latest-science-mcp@latestPMIDPMCIDDOIMESH_TERMISSN
PubMed Central Open Access SubsetMachine-reusable full-text subset of PubMed Central covering millions of biomedical journal articles and preprints published under open licenses.academiccorpusPMC-Open-Accessfreenonedaily incremental packages; full baseline snapshots twice yearly (mid-June, mid-December)yesmcp-needed-high-valueDOIPMIDPMCID
PubPeerPost-publication peer review platform hosting reader comments and integrity discussions attached to individual scientific publications.academiccorpusunknownfreeapi-key-freecontinuousnomcp-needed-low-valueDOIPMIDARXIV_ID
RCSB Protein Data BankPublic repository of experimentally-determined 3D structures of proteins, nucleic acids, and complexes plus integrative and computed structure models, run by the RCSB consortium as the US member of the worldwide PDB.bio-genomicsregistryCC0-1.0freenoneweekly release every Wednesday (00:00 UTC)yesmcp-existsPDB_IDUNIPROT_ACCESSIONDOIPMIDNCBI_TAXON_ID
ReactomeFree, open-source, curated, and peer-reviewed pathway database covering human biology with orthology projections to model organisms.bio-genomicsknowledge-graphCC0freenonequarterlyyesmcp-existsUNIPROT_ACCESSIONENSEMBL_IDGENE_SYMBOLCHEMBL_IDPMIDDOI
ReBEC (Brazilian Registry of Clinical Trials)Brazil's national WHO- and ICMJE-recognised primary clinical trials registry for experimental and non-experimental studies conducted on humans in Brazilian territory, run by Fiocruz for the Ministry of Health.clinical-biotechregistryunknownfreenonecontinuousnorequires-scrapingWHO_UTN
Reddit Data APIOfficial Reddit Data API exposing posts, comments, subreddits, users, and votes across the public Reddit network via OAuth2-authenticated REST endpoints.consumer-signalcorpusReddit-Data-API-Termsfreemiumoauthreal-timenomcp-existsURLWIKIDATA_QID
Retraction Watch DatabaseCurated registry of retracted, corrected, and otherwise flagged scholarly papers, with structured reasons, dates, and linked DOIs/PubMed IDs.academicregistrycrossref-metadata-freefreenoneupdated every working day by Retraction Watchyesmcp-existsDOIPMID
RfamEMBL-EBI database of RNA families, each represented by a curated seed alignment, consensus secondary structure, and covariance model used for genome annotation.bio-genomicsknowledge-graphCC0freenoneannual or semi-annual major releasesyesmcp-needed-low-valuePDB_IDMIRBASE_IDNCBI_TAXON_IDGO_IDPMID
ROR (Research Organization Registry)Global community-led registry of open persistent identifiers and metadata for research and funding organizations.academicregistryCC0freenoneat least monthly (community curation releases)yesmcp-needed-low-valueRORISNIWIKIDATA_QIDFUNDER_DOI
RxNormNLM normalized drug terminology that assigns each clinical drug a concept id (RxCUI) and cross-maps it to NDC, ATC, DrugBank, UNII, SPL, and other pharmacy vocabularies.clinical-biotechknowledge-graphUMLS-Metathesaurus-Licensefreenonemonthly full release (first Monday); weekly updates for Current Prescribable Contentyesmcp-existsnpm install -g medical-mcpRXNORM_CUINDCATC_CODEDRUGBANK_IDUNIISETIDHCPCSFDA_APPLICATION_NUMBER
S&P 500 Companies FinancialsStatic CSV roster of the 500 S&P 500 constituents with sector, ticker, SEC filings link, and a snapshot of common per-share valuation metrics.finance-marketsreference-tableODC-PDDL-1.0freenonead-hoc (script-triggered; constituents refreshed Feb 2026, financials refreshed Jun 2026)yesapi-direct-sufficientTICKER
SAM.gov Contract OpportunitiesUS federal contract opportunities (solicitations, awards, sources-sought, presolicitations) posted by federal agencies on SAM.gov.government-open-dataevent-streamUS-Government-Public-Domainfree-with-registrationapi-key-freecontinuousnomcp-existsUS_STATE_CODENAICS_CODEUEI
SBIR.gov (America's Seed Fund)US federal SBIR/STTR seed-fund award records, awarded small businesses, and open solicitations across the participating federal agencies.government-open-dataregistryUS-Government-Public-Domainfreenoneirregularyesmcp-needed-low-valueUS_STATE_CODE
SEC EDGARUS SEC system of all corporate filings (10-K, 10-Q, 8-K, S-1, 13F, etc.) with company metadata and structured XBRL financial facts.corporate-registrymixedUS-Government-Public-Domainfreenonereal-time for filings dissemination; nightly bulk ZIP refresh (~3am ET)yesmcp-existsCIKTICKERDATEURL
SEC EDGAR Company Facts (XBRL)Structured XBRL financial facts for US SEC filers, queryable per-company (company facts / concept) or per-period across all issuers (frames).finance-marketspanelUS-Government-Public-Domainfreenonewithin minutes of filing acceptance; nightly bulk companyfacts.zip refresh (~3am ET)yesmcp-existsCIKTICKERDATE
SEC Fails-to-Deliver DataSemi-monthly SEC files listing aggregate fails-to-deliver share balances per US equity security by settlement date, sourced from NSCC's Continuous Net Settlement system.finance-marketspanelUS-Government-Public-Domainfreenonesemi-monthlyyesmcp-needed-low-valueCUSIPTICKERDATE
SEC Form 13F HoldingsQuarterly institutional investment-manager portfolio holdings extracted from Form 13F EDGAR filings, released as flattened bulk data sets.finance-marketspanelUS-Government-Public-Domainfreenonequarterlyyesmcp-existsCIKCUSIP
SEC Form 4 Insider Transactions (EDGAR)Section 16 insider transaction reports (Forms 3/4/5) filed to SEC EDGAR, reporting officer, director, and 10%-owner trades in a company's securities.finance-marketsevent-streamUS-Government-Public-Domainfreenonecontinuous (filings accepted through the trading day); official flat-file data sets refreshed quarterlyyesmcp-existsdocker run -i --rm -e SEC_EDGAR_USER_AGENT='Name ([email protected])' stefanoamorelli/sec-edgar-mcp:latestpip install sec-edgar-mcp; python -m sec_edgar_mcp.server (set SEC_EDGAR_USER_AGENT)CIKTICKER
SEC Form ADV / IAPDUS regulatory registry of investment adviser firms and their representatives, sourced from Form ADV filings and published via Investment Adviser Public Disclosure.corporate-registryregistryUS-Government-Public-Domainfreenoneweb/JSON search updated daily; bulk CSV complete files monthly, historical files quarterlyyesmcp-needed-low-valueLEI
SEC Form N-CEN Fund CensusQuarterly flat-file extracts of Form N-CEN annual census filings by US registered investment companies, covering fund structure, service providers, and operational disclosures.finance-marketsregistryUS-Government-Public-Domainfreenonequarterlyyesmcp-needed-low-valueCIKLEI
SEC Form N-PORT Fund HoldingsQuarterly bulk data sets of monthly portfolio holdings reported by US registered management funds and ETFs on Form N-PORT, as tab-delimited relational tables.finance-marketspanelUS-Government-Public-Domainfreenonequarterly (data-set posting); underlying reports are monthly holdings as of each month-endyesmcp-needed-high-valueCIKCUSIPISINLEITICKER
Semantic ScholarAi2's scholarly knowledge graph covering 214M papers, 79M authors, and 2.49B citations across all disciplines, with paper-recommendation and bulk-snapshot endpoints.academicknowledge-graphCC-BY-NC-4.0free-non-commercialapi-key-freeweeklyyesmcp-existsDOIPMIDPMCIDARXIV_ID
SimFinStandardised company fundamentals (income statement, balance sheet, cash flow), daily share prices, and derived ratios for ~5,000 mostly-US public companies via REST API and bulk CSV.finance-marketspanelproprietaryfreemiumapi-key-freedailyyesmcp-existsTICKERDATE
Smithsonian Open AccessSmithsonian Institution's open metadata and media for 14M+ collection records across 19 museums, 9 research centers, libraries, archives, and the National Zoo, all CC0.government-open-datacorpusCC0-1.0freeapi-key-freeweeklyyesmcp-needed-low-valueWIKIDATA_QIDURL
Stack Exchange Data ExplorerWeb-based T-SQL query interface over a weekly read-only snapshot of every public Stack Exchange site (Stack Overflow plus 170+ communities), backed by the same data published as monthly Internet Archive dumps.consumer-signalcorpusCC-BY-SA-4.0freeaccount-requiredweeklyyesmcp-existsURLDATEWIKIDATA_QID
STB Carload Waybill SampleStratified sample of U.S. rail carload waybills (commodity, tonnage, revenue, origin/destination) collected by the Surface Transportation Board from large freight railroads.government-open-dataevent-streamUS-Government-Public-Domainfreenoneannualyesmcp-needed-low-value
STRINGDatabase of known and predicted protein-protein interactions across ~12,500 organisms, covering ~59M proteins and 20B+ functional associations from experiments, co-expression, text-mining, and genomic context.bio-genomicsknowledge-graphCC-BY-4.0freenonemajor version every 1-2 years (v12.0 current)yesmcp-existsUNIPROT_ACCESSIONENSEMBL_IDGENE_SYMBOL
SureChEMBLEMBL-EBI database of chemistry text-mined from patent documents, linking compounds extracted from patent full text and images to the patents that disclose them.clinical-biotechknowledge-graphCC0freenonerolling; reprocessed as new patents publish (SureChEMBL 2.0 pipeline)yesmcp-needed-low-valueINCHI_KEYCHEMBL_IDPATENT_PUBLICATION_NUMBER
TED (Tenders Electronic Daily)EU public procurement notices from the Supplement to the Official Journal, published daily with a free anonymous search API, bulk XML, and a Linked Open Data / SPARQL backend.government-open-dataevent-streamCC-BY-4.0freenonedailyyesmcp-existsISO_3NUTS
The Cancer Genome Atlas (TCGA, via Broad GDAC Firehose)Pan-cancer multi-omic atlas of ~11,000 tumour samples across 33 cancer types, processed and distributed by the Broad Institute GDAC Firehose pipeline as standardised level-3 datasets and analysis runs.bio-genomicsmixedTCGA-Data-Usefreenonefrozen; final stddata run 2016-01-28, final analyses run 2016-01-28 (released 2017), CPTAC AWG runs through 2020yesmcp-needed-high-valueGENE_SYMBOLENSEMBL_IDENTREZ_GENE_IDDOIPMID
The LensIntegrated scholarly-and-patent knowledge graph linking ~200M scholarly records to global patent documents, biological sequences, and patent-to-paper citations.academicknowledge-graphLens-Terms-of-Usefreemiumaccount-requiredyesmcp-needed-high-valueDOIPMIDPMCIDMAG_IDORCIDISSNRORISNIWIKIDATA_QIDFUNDER_DOIPATENT_PUBLICATION_NUMBERCPC_CODEINPADOC_FAMILY_ID
Therapeutic Target Database (TTD)Curated database of therapeutic protein and nucleic-acid targets linked to their drugs, diseases, biomarkers and pathways, classified by target druggability and development status.clinical-biotechknowledge-graphCC-BY-NC-4.0free-non-commercialnonebiennialyesmcp-needed-high-valueUNIPROT_ACCESSIONGENE_SYMBOLPDB_IDCHEBI_IDATC_CODE
Trading Economics CommoditiesLive and historical prices, forecasts, and metadata for ~100 commodities (energy, metals, agricultural, industrial, livestock, electricity, carbon) accessed via the Trading Economics markets API and web tables.finance-marketstime-seriesTrading-Economics-Proprietarypaidapi-key-paidintraday quotes during market hours; end-of-day snapshots; historical series go back decades for major contractsnomcp-existsDATEISO_4217
Twelve DataUnified financial market-data API for real-time and historical prices across stocks, ETFs, forex, crypto, indices, and commodities, plus reference and fundamentals data.finance-marketstime-seriesproprietaryfreemiumapi-key-freereal-time (streaming ~170ms via WebSocket; REST intraday to monthly intervals)nomcp-existspython src/server.py (local; set TWELVE_DATA_API_KEY) or use the hosted cloud serverTICKERISINCUSIPFIGIISO_4217DATE
UCSC Genome BrowserUCSC Genomics Institute's reference genome browser with assemblies, annotation tracks, and pairwise/multiple alignments for human, mouse, and thousands of other species, exposed via REST API, public MySQL, FTP, and Table Browser.bio-genomicsmixedMITfreenonetrack-by-track; most reference tracks refresh on a months cadence, MySQL servers sync weekly Monday mornings Pacificyesmcp-existsGENE_SYMBOLENSEMBL_IDRSIDENTREZ_GENE_IDDOI
UK BiobankDeep-phenotyped longitudinal cohort of ~500,000 UK adults with whole-genome sequencing, imaging, biomarkers, lifestyle questionnaires, and linked NHS hospital, cancer, death, and primary-care records. Access is by approved application only.public-healthpanelUKB-Material-Transfer-Agreementpaiddars-or-equivalentrolling additions; major data refreshes (imaging, sequencing, linked EHR) on a multi-month cycleyesmcp-needed-low-valueICD_10OPCS_4BNF_CODEGENE_SYMBOLENSEMBL_IDRSID
UKRI Gateway to Research (GtR)UK Research and Innovation's registry of publicly funded research projects, linked to funding, people, organisations, and outcomes.government-open-dataknowledge-graphOGL-3.0freenoneperiodic (data refreshed roughly monthly)noapi-direct-sufficientORCID
UMLS MetathesaurusNLM's Unified Medical Language System Metathesaurus, a concept graph that crosswalks 200+ biomedical vocabularies (SNOMED CT, RxNorm, LOINC, ICD-10, MeSH, CPT) under shared Concept Unique Identifiers.clinical-biotechknowledge-graphUMLS-Licensefree-with-registrationaccount-requiredbiannual (AA release ~May, AB release ~November)yesmcp-existsMESH_TERMICD_10RXNORM_CUICPTHCPCSMEDDRA_TERMATC_CODEUMLS_CUISNOMED_CT_IDLOINC_CODE
UN ComtradeOfficial United Nations repository of annual and monthly international merchandise (and services) trade statistics, bilateral by reporter, partner, and commodity code.government-open-datapanelUN-Comtrade-Termsfree-with-registrationapi-key-freemonthlyyesmcp-needed-high-valueISO_3DATEHS_CODE
UN/LOCODE (United Nations Code for Trade and Transport Locations)UNECE-maintained five-character code list identifying ports, airports, rail terminals, inland depots, and border crossings worldwide, used in trade and transport documentation.government-open-datareference-tableODC-PDDL-1.0freenonebiannual (July and December releases)yesmcp-needed-low-valueISO_2ISO_3
UniProtComprehensive, freely accessible protein sequence and functional annotation resource maintained by the UniProt Consortium (EMBL-EBI, SIB, PIR), with REST API, FTP bulk downloads, and rich cross-references to genomic, structural, and clinical databases.bio-genomicsregistryCC-BY-4.0freenone8-week release cycleyesmcp-existsUNIPROT_ACCESSIONGENE_SYMBOLENSEMBL_IDPMIDDOICHEMBL_ID
UnpaywallOpen database of free, legal open-access (OA) full-text locations for scholarly articles, keyed by DOI.academicregistryCC0freemiumnonecontinuous (API); periodic JSONL snapshotyesmcp-needed-low-valueDOIISSN
US Census International Trade APIMonthly US import and export statistics by commodity, country, district, port, and state, from the Census Bureau's foreign-trade program.government-open-datapanelUS-Government-Public-Domainfreeapi-key-freemonthlynomcp-existsDATEHS_CODE
US Treasury Fiscal DataOfficial machine-readable home for US federal fiscal data (debt, interest rates, securities auctions, receipts, outlays, exchange rates) published by the Treasury Bureau of the Fiscal Service.finance-marketsmixedUS-Government-Public-Domainfreenonedataset-dependent: daily (debt-to-penny), monthly, quarterlyyesmcp-existsCUSIPDATE
USACE Waterborne Commerce Statistics (WCSC)Official US Army Corps of Engineers statistics on domestic and foreign waterborne cargo tonnage and vessel trips, by port, commodity, and waterway.government-open-datamixedUS-Government-Public-Domainfreenoneannual final report; monthly preliminary indicatorsyesmcp-needed-low-valueDATEUS_STATE_CODE
USAspending.govOfficial U.S. government record of federal spending — contracts, grants, loans, and other awards, plus agency account balances, from FY2008 to present.government-open-datamixedUS-Government-Public-Domainfreenonedailyyesmcp-existsFIPSUS_STATE_CODEISO_3NAICS_CODEUEI
USPTO Open Data Portal (Patents)US Patent and Trademark Office's Open Data Portal, the successor to the PatentsView Search API and PEDS, covering all granted US patents and published applications with disambiguated assignee/inventor data, CPC/USPC classification, citations, and full prosecution (Patent File Wrapper) records.government-open-dataregistryUS-Government-Public-Domainfree-with-registrationapi-key-freedaily refresh for Patent File Wrapper; granted patents weekly (Tuesday grant cycle)yesmcp-needed-high-valuePATENT_PUBLICATION_NUMBERCPC_CODE
VC Deal Flow SignalQuarterly longitudinal panel of GitHub engineering-velocity metrics across ~55 venture-backed startups and ~20 sectors, hosted on Hugging Face as three CSV/Parquet configurations.finance-marketspanelCC-BY-4.0freenonequarterlyyesmcp-existsDATE
Visa Onchain Analytics DashboardFree public web dashboard, built by Visa with Allium Labs, charting fiat-backed stablecoin supply, transfers, addresses, and lending across 19+ public blockchains.finance-marketspanelvisa-onchain-dashboard-proprietary-display-onlyfreenonedaily (per Allium upstream aggregation; not stated on dashboard itself)norequires-scrapingDATEISO_4217
VivliIndependent non-profit repository and secure research environment for de-identified individual participant-level data (IPD) from completed clinical trials, with a public metadata search index and controlled access to the underlying datasets.clinical-biotechregistryVivli-Data-Use-Agreementfree-with-registrationdars-or-equivalentcontinuous; new studies listed as sponsors and contributors add themnomcp-needed-low-valueNCT_IDDOI
WHO FluNetWHO global influenza surveillance combining weekly reports from ~150 National Influenza Centres into a unified view of virological detections, subtype distribution, and positivity rates.public-healthtime-seriesCC-BY-NC-SA-3.0-IGOfreenoneweeklyyesmcp-needed-low-valueISO_3DATE
WHO ICTRP (International Clinical Trials Registry Platform)WHO meta-registry that aggregates clinical trial records from primary and partner registries worldwide into a single searchable data set keyed on a common trial-registration schema.clinical-biotechregistryWHO-ICTRP-Terms-of-Usefree-non-commercialnoneweeklyyesmcp-existsNCT_IDEUDRACT_NUMBERWHO_UTN
Wikidata Query ServicePublic SPARQL endpoint over Wikidata's CC0 knowledge graph of 120M+ items, hubbing identifiers from DOI and ORCID to ISBN, NCT_ID, CHEMBL_ID, OSM_ID and most other cross-domain keys.government-open-dataknowledge-graphCC0freenonelive mirror of Wikidata edits; full RDF dumps weeklyyesmcp-existsWIKIDATA_QIDWIKIPEDIA_ARTICLEDOIPMIDPMCIDARXIV_IDORCIDISNIRORISSNISBNNCT_IDCHEMBL_IDDRUGBANK_IDUNIIATC_CODEUNIPROT_ACCESSIONENSEMBL_IDENTREZ_GENE_IDNCBI_TAXON_IDCIKLEIISO_3ISO_2OSM_IDMESH_TERM
Wikipedia Pageviews APIWikimedia REST endpoints exposing per-article and aggregate pageview counts for all Wikimedia projects, daily/monthly granularity, back to July 2015.consumer-signaltime-seriesCC0freenonedailyyesmcp-needed-high-valueURLDATEISO_3WIKIDATA_QID
WIPO PATENTSCOPEWIPO's free search service over 128M patent documents, including 5.4M published PCT international applications plus national and regional collections.government-open-dataregistryWIPO-Terms-of-UsefreemiumnonePCT weekly (Thursdays), daily bibliographic updates; national collections ad hoc per officeyesmcp-needed-high-valuePATENT_PUBLICATION_NUMBER
WITHDRAWNCurated database of withdrawn and discontinued drugs with withdrawal reasons, toxicity classification, targets, and ATC classes.clinical-biotechregistryunknownfreenoneirregularyesmcp-needed-low-valueATC_CODEINCHI_KEYCHEMBL_IDDRUGBANK_IDUNIPROT_ACCESSIONGENE_SYMBOL
World Bank Commodity Prices (Pink Sheet)World Bank's monthly Pink Sheet of global commodity price benchmarks across energy, agriculture, fertilizers, metals, and precious metals, published as Excel workbooks with full monthly history back to 1960 and annual aggregates.finance-marketstime-seriesCC-BY-4.0freenonemonthlyyesmcp-needed-low-valueDATEISO_4217
World Bank Open DataWorld Bank's free catalogue of global development statistics covering 16,000+ indicators across 200+ economies, with REST API, bulk downloads, and an official MCP for the newer Data360 platform.government-open-datamixedCC-BY-4.0freenonevaries by indicator (annual, quarterly, monthly)yesmcp-existsISO_2ISO_3
X (Twitter) APIReal-time and full-archive access to X (Twitter) posts, users, search, trends, and news stories via the v2 REST API, exposed to agents through X's official hosted MCP server.consumer-signalevent-streamX-Developer-Agreementpaidoauthreal-timenomcp-existsURLISO_639_1
yfinanceUnofficial Python wrapper around Yahoo Finance's undocumented JSON endpoints for historical OHLCV prices, fundamentals, options chains, dividends, splits, and corporate actions.finance-marketstime-seriesApache-2.0freenonecontinuousnofragile-unofficialTICKERISIN
YODA Project (Yale Open Data Access)Yale-based data-sharing intermediary that brokers controlled access to individual participant data (IPD) and clinical study reports from 500+ industry-sponsored clinical trials via a formal data-request and DUA process.clinical-biotechregistryYODA-Data-Use-Agreementfree-with-registrationdars-or-equivalentirregular; new trials and data partners added over time (J&J, Medtronic, Kenvue, QMUL, SI-BONE)norequires-scrapingNCT_ID